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Structural basis for human ZBTB7A action at the fetal globin promoter.
Yang Y, Ren R, Ly LC, Horton JR, Li F, Quinlan KGR, Crossley M, Shi Y, Cheng X. Yang Y, et al. Cell Rep. 2021 Sep 28;36(13):109759. doi: 10.1016/j.celrep.2021.109759. Cell Rep. 2021. PMID: 34592153 Free PMC article.
Here, we describe X-ray structures of the ZBTB7A DNA-binding domain, consisting of four adjacent ZFs, in complex with the -200 sequence element, which contains two copies of four consecutive C:G base pairs. ...Our results firmly establish ZBTB7A/LRF as a key molecul …
Here, we describe X-ray structures of the ZBTB7A DNA-binding domain, consisting of four adjacent ZFs, in complex with the -200 sequen …
LRF/ZBTB7A conservation accentuates its potential as a therapeutic target for the hematopoietic disorders.
Chondrou V, Markopoulos GS, Patrinos GP, Kouraklis-Symeonidis A, Symeonidis A, Papachatzopoulou A, Sgourou A. Chondrou V, et al. Gene. 2020 Nov 15;760:145020. doi: 10.1016/j.gene.2020.145020. Epub 2020 Aug 2. Gene. 2020. PMID: 32755656
Conserved sequences across species have always provided valuable insights to improve our understanding on the human genome's entity and the interplay among different loci. Lymphoma/leukemia related factor (LRF) is encoded by ZBTB7A gene and belongs to an evolutionar …
Conserved sequences across species have always provided valuable insights to improve our understanding on the human genome's entity and the …
Expression of Zinc Finger and BTB Domain-containing 7A in Colorectal Carcinoma.
Joo JW, Kim HS, Do SI, Sung JY. Joo JW, et al. Anticancer Res. 2018 May;38(5):2787-2792. doi: 10.21873/anticanres.12522. Anticancer Res. 2018. PMID: 29715100
However, the expression of ZBTB7A in colorectal carcinoma (CRC) has seldom been documented. In this study, we investigated the differential expression of ZBTB7A in CRC cell lines and tissues. ...Our data suggest that ZBTB7A is involved in the development and …
However, the expression of ZBTB7A in colorectal carcinoma (CRC) has seldom been documented. In this study, we investigated the differ …
Utility of LRF/Pokemon and NOTCH1 protein expression in the distinction between nodular lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphoma.
Bohn O, Maeda T, Filatov A, Lunardi A, Pandolfi PP, Teruya-Feldstein J. Bohn O, et al. Int J Surg Pathol. 2014 Feb;22(1):6-11. doi: 10.1177/1066896913513833. Epub 2013 Dec 10. Int J Surg Pathol. 2014. PMID: 24326827 Free PMC article.
Classical Hodgkin lymphoma (CHL) and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) are considered separate entities with different prognosis and treatment. ...LRF/Pokemon is a proto-oncogene, an interacting partner co-expressed with BCL6 in germinal center …
Classical Hodgkin lymphoma (CHL) and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) are considered separate entities …
POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function.
Lee SU, Maeda T. Lee SU, et al. Immunol Rev. 2012 May;247(1):107-19. doi: 10.1111/j.1600-065X.2012.01116.x. Immunol Rev. 2012. PMID: 22500835 Free PMC article. Review.
The GC response is tightly regulated during clonal expansion, immunoglobulin modification, and affinity maturation, whereas its deregulation has a detrimental effect on immune function, leading to development of diseases, such as lymphoma and autoimmunity. LRF (lymphoma …
The GC response is tightly regulated during clonal expansion, immunoglobulin modification, and affinity maturation, whereas its deregulation …
Leukemia/lymphoma-related factor (LRF) exhibits stage- and context-dependent transcriptional controls in the oligodendrocyte lineage and modulates remyelination.
Davidson NL, Yu F, Kijpaisalratana N, Le TQ, Beer LA, Radomski KL, Armstrong RC. Davidson NL, et al. J Neurosci Res. 2017 Dec;95(12):2391-2408. doi: 10.1002/jnr.24083. Epub 2017 May 30. J Neurosci Res. 2017. PMID: 28556945 Free PMC article.
Leukemia/lymphoma-related factor (LRF), a zinc-finger transcription factor encoded by Zbtb7a, is a protooncogene that regulates differentiation in diverse cell lineages, and in the CNS, its function is relatively unexplored. ...LRF knockdown earlier within the oligo …
Leukemia/lymphoma-related factor (LRF), a zinc-finger transcription factor encoded by Zbtb7a, is a protooncogene that regulate …
Expression of leukemia/lymphoma-related factor (LRF/POKEMON) in human breast carcinoma and other cancers.
Aggarwal A, Hunter WJ 3rd, Aggarwal H, Silva ED, Davey MS, Murphy RF, Agrawal DK. Aggarwal A, et al. Exp Mol Pathol. 2010 Oct;89(2):140-8. doi: 10.1016/j.yexmp.2010.05.002. Epub 2010 May 21. Exp Mol Pathol. 2010. PMID: 20471975 Free PMC article.
The POK family of proteins plays an important role in not only embryonic development and cell differentiation, but also in oncogenesis. Leukemia/lymphoma-related factor (LRF) belongs to the POK family of transcriptional repressors and is also known as POK erythroid myeloid …
The POK family of proteins plays an important role in not only embryonic development and cell differentiation, but also in oncogenesis. Leuk …
Role of LRF/Pokemon in lineage fate decisions.
Lunardi A, Guarnerio J, Wang G, Maeda T, Pandolfi PP. Lunardi A, et al. Blood. 2013 Apr 11;121(15):2845-53. doi: 10.1182/blood-2012-11-292037. Epub 2013 Feb 8. Blood. 2013. PMID: 23396304 Free PMC article. Review.
Generally considered transcriptional repressors, several of these genes play fundamental roles in cell lineage fate decision in various tissues, programming specific tasks throughout the life of the organism. Here, we focus on functions of leukemia/lymphoma-related factor/ …
Generally considered transcriptional repressors, several of these genes play fundamental roles in cell lineage fate decision in various tiss …
Landscape of driver mutations and their clinical effects on Down syndrome-related myeloid neoplasms.
Sato T, Yoshida K, Toki T, Kanezaki R, Terui K, Saiki R, Ojima M, Ochi Y, Mizuno S, Yoshihara M, Uechi T, Kenmochi N, Tanaka S, Matsubayashi J, Kisai K, Kudo K, Yuzawa K, Takahashi Y, Tanaka T, Yamamoto Y, Kobayashi A, Kamio T, Sasaki S, Shiraishi Y, Chiba K, Tanaka H, Muramatsu H, Hama A, Hasegawa D, Sato A, Koh K, Karakawa S, Kobayashi M, Hara J, Taneyama Y, Imai C, Hasegawa D, Fujita N, Yoshitomi M, Iwamoto S, Yamato G, Saida S, Kiyokawa N, Deguchi T, Ito M, Matsuo H, Adachi S Prof, Hayashi Y, Taga T, Moriya Saito A, Horibe K, Watanabe K, Tomizawa D, Miyano S, Takahashi S, Ogawa S, Ito E. Sato T, et al. Blood. 2024 Mar 21:blood.2023022247. doi: 10.1182/blood.2023022247. Online ahead of print. Blood. 2024. PMID: 38513239
Sixteen novel mutational targets were identified in ML-DS samples. Of these, inactivations of IRX1 (16.2%) and ZBTB7A (13.2%) were commonly implicated in the upregulation of the MYC pathway and were potential targets for ML-DS treatment with bromodomain-containing protein …
Sixteen novel mutational targets were identified in ML-DS samples. Of these, inactivations of IRX1 (16.2%) and ZBTB7A (13.2%) were co …
The clinical mutatome of core binding factor leukemia.
Opatz S, Bamopoulos SA, Metzeler KH, Herold T, Ksienzyk B, Bräundl K, Tschuri S, Vosberg S, Konstandin NP, Wang C, Hartmann L, Graf A, Krebs S, Blum H, Schneider S, Thiede C, Middeke JM, Stölzel F, Röllig C, Schetelig J, Ehninger G, Krämer A, Braess J, Görlich D, Sauerland MC, Berdel WE, Wörmann BJ, Hiddemann W, Spiekermann K, Bohlander SK, Greif PA. Opatz S, et al. Leukemia. 2020 Jun;34(6):1553-1562. doi: 10.1038/s41375-019-0697-0. Epub 2020 Jan 2. Leukemia. 2020. PMID: 31896782 Free PMC article.
Thereby, we detected fundamental differences between CBFB/MYH11- and RUNX1/RUNX1T1-rearranged patients with ASXL2, JAK2, JAK3, RAD21, TET2, and ZBTB7A being strongly correlated with the latter subgroup. We found prognostic relevance of mutations in genes previously known t …
Thereby, we detected fundamental differences between CBFB/MYH11- and RUNX1/RUNX1T1-rearranged patients with ASXL2, JAK2, JAK3, RAD21, TET2, …
35 results